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Restoring and Sustaining Energy

D-ribose/ribose FAQs

What is D-Ribose?
D-Ribose is a five-carbon, monosaccharide, or pentose sugar. It is used by all cells in the body and is an essential component in energy metabolism. It also provides the structural backbone for DNA, RNA and certain vitamins.
What is the source of D-Ribose? 
D-ribose is a simple sugar that is produced through a natural fermentation process. Ribose is obtained through a series of purification steps monitored under stringent Quality Control and Quality Assurance protocols.

Does it have US GRAS status?
Yes, it has GRAS status from US Food and Drug Administration (FDA). GRAS (Generally Recognized As Safe) is a designation given to any substance that has been successfully subjected to review (efficacy, safety, manufacturing process)  by an independent scientific committee and approved by the FDA or to an ingredient that is generally recognized, among qualified experts, as having been adequately shown to be safe under the conditions of its intended use.

How does ribose facilitate energy formation?
D-Ribose is used by cells and tissues to synthesize ATP, the primary source of energy used by all cells.

Does your body produce D-Ribose?
Although every cell in the body makes ribose, heart and muscle tissues make ribose slowly when you need to restore low levels of energy.

How is ribose made in the body?
All the necessary constituents for life are made in the body through a series of complicated biochemical metabolic pathways. In the body, D-ribose is made from glucose through a metabolic pathway called the Pentose Phosphate Pathway (PPP) or Hexose Monophosphate Shunt (HMS). However, in heart and muscle cells the important enzymes that regulate the activity of this pathway are lacking. As a result, ribose formation in heart and muscle cells is a slow process. The delay in ribose synthesis in heart and muscle tissues also impedes energy recovery when energy levels have been depleted by disease or exercise. 

How does taking supplemental ribose aid in increasing cellular energy?
If the cellular energy pool is depleted by disease, overwork, or exercise it must be replaced. Supplemental ribose bypasses the slow Pentose Phosphate Pathway, resulting in acceleration of the process of energy synthesis.

Can you get sufficient D-Ribose in food?
While ribose precursors (e.g., glucose) are ubiquitous in living matter and ingested in our diets, ribose does not exist as a free standing compound in foods. Rather, ribose must be created in the body from other compounds, such as glucose.

In energy depleted tissues, ribose cannot be produced quickly enough to meet the cellular energy demands.

As a sugar, does D-Ribose alter the glycemic load?
No, pure D-ribose does not add to the glycemic load. Unlike glucose, a six carbon sugar, ribose is a five carbon sugar and is not recognized as a fuel by the body. Cells have developed enzymatic pathways to keep D-ribose from being metabolized for fuel like glucose. These protective pathways ensure that D-ribose is available for the synthesis of cellular energy in the form of ATP.

Because D-ribose is not burned as a fuel, it does not cause an insulin spike or elevate blood glucose levels following consumption.

Are there any side effects of D-Ribose?
D-Ribose has been very well tolerated in clinical trials. Occasional side effects include mild and transient hypoglycemia, diarrhea, nausea, or headache.